Chromatography Columns for Bioprocessing (2024)

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Chromatography Columns for Bioprocessing

Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale, delivering robust and consistent performance with the processing flexibility you need for anything from screening to large-scale production.

Read more about

  • Vantage® columns for research, development, and production
  • QuikScale®scalable family of columns
  • IsoPak™ columns for process-scale applications

Vantage®columns for research, development, and production

Vantage®chromatography columns are ideal for development, pilot, or production purification in pharmaceutical and biotechnology applications. Vantage®columns are designed for simple assembly, scalability from R&D to pilot at small-scale production, and zero dead space.

  • Our Vantage®L family of laboratory columns for research and development are ideally suited for small-particle media applications
  • Our Vantage®A2 family of chromatography columns are well-suited for rigid, higher-resolution chromatography media
  • Our Vantage®S2 chromatography columns provide flexibility for a wide range of applications

Chromatography Columns for Bioprocessing (2)

QuikScale®scalable family of columns

This robust, scalable family of chromatography columns maximizes process yields, boosts productivity, and shortens time to market. QuikScale® columns achieve ultra-high throughput and deliver greater product purity – at faster linear velocities. They accommodate all media types, are easily and uniformly packed, and deliver optimal resolution across a wide range of applications.

An innovative flow distributor ensures full, uniform media utilization for reproducible and reliable separations. A high-flow option (with operating pressures up to 7 bar and flow rates up to 1,000 cm/hr) maximizes process design flexibility. This allows greater bed height settings when handling media with high flow and/or back pressure requirements.

QuikScale® chromatography columns are designed for:

  • Scalability with a full range of column diameters (from 70 mm to 630 mm) and heights (550 mm to 1,100 mm), as well as bed support pore size (10, 20, and 30 µm)
  • Wide variety of applications – thanks to multiple tube materials (glass, acrylic, stainless steel)

Chromatography Columns for Bioprocessing (3)

IsoPak™ columns for process-scale applications

IsoPak™ columns are fast and highly reproducible, delivering consistent chromatographic results that are ideal for process-scale applications. What sets an IsoPak™ column apart is its reproducible packing and unpacking. Due to a unique valve design, slurry is pumped directly into the column, enabling the column to be packed and unpacked without the removal of the top flow cell. By enclosing operations, exposure between the operator and the chromatographic media is drastically limited.

IsoPak™ columns are available in a wide range of diameters (440 to 1,400 mm and higher), tubing materials, and bed heights (500 to 1,000 mm). They provide:

  • Consistent packing and unpacking for reproducible results
  • Ease of maintenance
  • Scalability

Related Product Resources

  • Data Sheet: Vantage® L Biochromatography Columns

    Vantage® L laboratory columns provide advanced design for the increased demands of biochromatography.

  • Data Sheet: Vantage® A2 Chromatography Process Columns

    Ideal for development, pilot, or production purification in the pharmaceutical biotechnology industry.

  • Data Sheet: Vantage® S2 Chromatography Process Columns

    Sanitary, for development, pilot, or production purification

  • Data Sheet: Isopak™ Biochromatography Columns

    Faster, cleaner, and more reproducible packing and unpacking for process scale chromatography columns

  • Spare Parts for IsoPak™ Chromatography Columns

    Spare Parts List

  • Data Sheet: QuikScale® Biochromatography Columns

    Innovative chromatography columns for scalable, rapid purification

  • Spare Parts for QuikScale® Chromatography Columns (70/100/140 mm)

    Spare Parts List

  • Spare Parts for QuikScale® Chromatography Columns (200/250/300 mm)

    Spare Parts List

  • Spare Parts for QuikScale® Chromatography Columns (350/450/630 mm

    Spare Parts List

  • Tech Brief: Consistent and Predictable Process Scale-up with QuikScale® Biochromatography Columns

    QuikScale® columns offer a broad range of performance capabilities—a greater than 400 to 1 range in processing capability with each column size designed to provide proven and consistent performance.

  • Brochure: Process Development and Drug Manufacturing: Support Services

    We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.

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Related Product Categories

Chromatography Systems for Bioprocessing

Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.

Affinity Chromatography Resins

Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.

Enhance filtration with our advanced tangential flow systems. Minimized hold-up, high concentration, and impeccable recovery for varied applications.

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To help you navigate the highly regulated and complex pharmaceutical and biotechnology industries, we offer a wide range of qualification services to ensure that your system is fully operational for your specific process.

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Chromatography Columns for Bioprocessing (2024)

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